Bacterial and Viral Diseases Research Directorate

Background

Bacterial and Viral Diseases Research Directorate (BVDRD) is one of the research Directorates working on clinically important bacterial, viral and fungal diseases including but not limited to improve detection of clinically important invasive bacterial and viral pathogens; understanding antibacterial drug resistance; chronic hepatitis; Fungal Biology and Pathogenicity; viral oncogenes and Tropical and emerging viral pathogens.

 

The BVDRD is comprised of researchers who work to understand bacteria, viruses and funguses from a variety of perspectives including basic biological processes, the microbiome in health and disease, mechanisms by which some microbes cause disease and the development of vaccines, diagnostic methods and novel therapeutic approaches. The BVDRD also provides an excellent training environment for graduate and undergraduate students. Currently there are 14 PhD and 7 MSc students who are doing their research under the directorate.

 

Major Area of the Research

  • Clinical Genomics and Diagnostics
  • Antimicrobial resistance
  • Polymicrobial infections
  • Emerging infectious diseases
  • Host-pathogen interactions

Current Projects/Studies/Activities

  • Severe Typhoid in Africa (SETA) Program
  • Bacterial Meningitis
  • Epidemiology and molecular characteristics of extended spectrum beta lactamase producing Enterobacteriaceae at Jimma University Teaching Hospital, Ethiopia
  • Phenotypic detection and Molecular characterization of extended-spectrum beta lactamase genes from clinical isolates of Enterobacteriaceae in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia
  • Phenotypic and Molecular Characterization  Drug Resistance in Klebsiella Pneumoniae Isolated from Patients at Tikur Anbesa Specialized Hospital
  • Characterization of the interaction of microbiota and pathogenic enteric bacteria in an Ethiopian traditional fermented food
  • Identification of Akaki River Pollutants; Their biological effect on Livestock and Human in Addis Ababa Ethiopia 
  • Phenotypic and Molecular Characterization of Potential Pathogenic Bacteria in Akaki River and their Biological Effect on Model Organism, Ethiopia
  • Phenotypic and Genotypic Characterizations of Streptococcus pneumoniae Strains Isolated from Pediatric Patients in Addis Ababa, Ethiopia
  • Molecular epidemiology of carbapenems resistance and Extended spectrum beta-lactamase producing Enterobacteriaceae among septicemia suspected children in Addis Ababa, Ethiopia
  • Role of viral hepatitis and their genotype on Hepatocellular carcinoma (HCC) and chronic liver disease (CLD) in southern and central Ethiopia
  • Molecular Epidemiology of Hepatitis B Virus Genotypes and pattern of mutations among HIV Co-infected and HBV Mono-infected Adults
  • Characterizing the Unmet HIV Prevention Needs and HIV Risk Vulnerabilities of Adolescent Girls and Young Women in Ethiopia
  • Cohort Event Monitoring of Antiretrovirals in Addis Ababa, Ethiopia
  • Impact of rotavirus vaccine on rotavirus prevalence, molecular genetics and immune responses: An immune-genetic comparative study
  • Molecular characterization of Measles virus from confirmed Measles Outbreak in Ethiopia between 2015 and 2017 
  • Viral and bacterial etiology of severe acute respiratory illness among children

Achievements

  • One policy brief on meningitis prepared and submitted to MoH
  • Two EMJ special supplementary issues are under preparation from MoH funded clinical research on Hepatitis and Antimicrobial Research

Recent Publication in 2010 EFY (2017/18)

  • Cooper LV, Boukary RM, Aseffa A, Mihret W, Collard JM, Daugla D, Hodgson A, Sokhna C, Omotara B, Sow S, Quaye SL, Diallo K, Manigart O, Maiden MCJ, Findlow H, Borrow R, Stuart JM, Greenwood BM, Trotter CLInvestigation of correlates of protection against pharyngeal carriage of Neisseria meningitidis genogroups W and Y in the African meningitis belt. PLoS One. 2017;12(8):e0182575
  • Adal M, Howe R, Kassa D, Aseffa A, Petros B.  Malnutrition and lipid abnormalities in antiretroviral naïve HIV-infected adults in Addis Ababa: A cross-sectional study. PLoS One. 2018; 13(4):e0195942.
  • Bitew Kifilie A, Dagnew M, Tegenie B, Yeshitela B, Howe R, Abate E. Bacterial Profile, Antibacterial Resistance Pattern, and Associated Factors from Women Attending Postnatal Health Service at University of Gondar Teaching Hospital, Northwest Ethiopia. Int J Microbiol. 2018;2018:3165391
  • G/Eyesus T, Moges, F., Eshetie, S., Yeshitela, B., & Abate, E. (2017). Bacterial etiologic agents causing neonatal sepsis and associated risk factors in Gondar, Northwest Ethiopia. BMC pediatrics17(1), 137.
  • Sharew B, Mulu A, Teka B, Tesfaye T HIV-Sero-prevalence trend among blood donors in North East Ethiopia. Afr Health Sci. 2017 Sep;17(3):712-718
  • Mulu A, Maier M, Liebert UG.  Upward trends of acquired drug resistances in Ethiopian HIV-1C isolates: A decade longitudinal study. . PLoS One. 2017 Oct 19
  • Mekonnen D, Derbie A, Biadglegne F, Adem Y, Zenebe Y, Mekonnen H, Gebeyaw A, Shumet A, Bereded F, Hailu D, Elfu B, Mihret A, Sack U. Knowledge and practice on magnitude, diagnosis, treatment and prevention strategies of Hepatocellular Carcinoma in Ethiopia: A Systematic Review. J. Health Dev. 2017;31(1):44-56

Bacteriology Resources

Title Date Document Type Attachments
The Typhoid Fever Surveillance in Africa Program (TSAP): Clinical, Diagnostic, and Epidemiological Methodologies 2016-05-12 11:42 Publications, Bacteriology The Typhoid Fever Surveillance in Africa Program (TSAP).pdf
The Relationship Between Invasive Nontyphoidal Salmonella Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa 2016-05-12 11:41 Publications, Bacteriology The Relationship Between Invasive Nontyphoidal Clin Infect Dis.-2016-Park-S23-31(1).pdf
Bloodstream Infections and Frequency of Pretreatment Associated With Age and Hospitalization Status in Sub-Saharan Africa 2016-05-12 11:37 Publications, Bacteriology Bloodstream Infections and Frequency Clin Infect Dis.-2015-Nichols-S372-9.pdf
A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt 2016-04-20 15:02 Publications, Bacteriology A Seroepidemiological Study of Serogroup A PLoS ONE Journal .pdf
Utilization of Healthcare in the Typhoid Fever Surveillance in Africa Program 2016-04-20 15:00 Publications, Bacteriology Utilization of Healthcare in the Typhoid Fever Surveillance Clin Infect Dis.-2016-Panzner-S56-68(1).pdf
Meningococcal carriage in the African meningitis belt 2015-09-15 12:36 Publications, Bacteriology Bacteriology 4.pdf
A pilot study on detection and genotyping of Human Papilloma virus isolated from clinically diagnosed Ethiopian women having cervical intraepithelial neoplasia 2015-09-15 12:33 Publications, Bacteriology Bacteriology 3.pdf
Chronic meningitis in immunocompromised adult Ethiopians visiting Tikur Anbessa Teaching Hospital and Ye’huleshet Clinic from 22003-2004 2015-09-15 12:26 Publications, Bacteriology Bacteriology 2.pdf
The Diversity of Meningococcal Carriage Acrossthe African Meningitis Belt and the Impact ofVaccination With a Group A MeningococcalConjugate Vaccine 2015-09-15 12:17 Publications, Bacteriology Bacteriology 1.pdf