Bacteriology

Background

Bacteriology team at AHRI was established in 2006 in order to conduct epidemiological and molecular studies on common bacterial diseases including meningitis, Streptococcus pneumoniae and typhoid fever.  The overall goal of the team is to characterize and identify diseases with bacterial etiology agents in different geographical areas of Ethiopia. Investigations on carriage of bacterial diseases are also focused to get a highlight for future vaccine intervention studies.  By doing so, the team provide basic information to policy makers and improve public health.

Major Area of the Research

  • Bacterial meningitis and risk factors affecting meningococcal disease severity
  • Typhoid Fever and other bacterial causes of sepsis
  • Impact of Ten-valent pneumococcal conjugate vaccine (PCV10) on Streptococcus pneumoniae
  • Hospital acquired infection and anti-microbial resistance
  • Molecular epidemiology and disease severity of bacterial meningitis

Current Projects/Studies/Activities

  • Surveillance of bacterial meningitis in Ethiopia and examining factors affecting meningococcal disease severity (leaded and coordinated by the capacity building arm “Study on the etiologies and severity of Bacterial meningitis in Ethiopia”)
  • The impact of Ten-valent pneumococcal conjugate vaccine (PCV10) on Streptococcus pneumoniae nasopharyngeal carriage rate: phenotypic and genetic diversity of isolates from Addis Ababa, Ethiopia.
  • A Comparative Study of Blood Culture and Widal test in Diagnosis of Typhoid Fever in Febrile Patients visiting selected Health Centers, Addis Ababa, Ethiopia.
  • Enhanced Sentinel System For Surveillance of Bacterial Meningitis In Ethiopia.
  • Systematic study of hospital acquired infections and antibiotic resistance: insight in to the epidemiology and genetics of infection.

Achievements

Previous studies report that N. meningitidis serogroup A was the main cause of meningitis. In comparison with other serogroups of N. meningitidis, higher detection  rate of serogroup A was expected. Though serogroup A was not detected in the carriage study, it was later isolated in other study focusing on bacterial meningitis patients. Serogroup X was identified for the first time in a consortium study among three site University hospitals in bacterial meningitis disease focusing in detection of etiologic agents in the non-epidemic season. Serogroup W-135 was  detected in increased frequency with respect to the relatively smaller sample size of the consortium study. Serogroup W -135, X and Y are also detected in later carriage study. Vaccine clinical trial targeting on serogroup A and serogroup W-135 is planned.

 

Recent Publication

  • The Diversity of Meningococcal Carriage acrossthe African Meningitis Belt and the Impact ofVaccination with a Group A Meningococcal Conjugate Vaccine. Journal of Infectious Diseases Advance Access published May 12, 2015. Author name: MenAfriCAR Consortium
  • Chronic meningitis in immunocompromised adult Ethiopians visiting TikurAnbessa Teaching Hospital and Ye’huleshet Clinic from 2003-2004.Ethiop Med J,Sup 1,43-47.Jan. 2014. Author Name: WudeMhiret
  • A pilot study on detection and genotyping of human papilloma viruse isolated from clinically diagnosed Ethiopian women having cervical intraephitelialneoplasia.Ethiop Med J,Sup 1,49-51. Jan. 2014. Author Name: WudeMhiret
  • Meningococcal carriage in the African meningitis belt.Tropical Medicine and International Health18:8 968–978 August 2013. Author Name: MenAfriCAR Consortium
  • Household Crowding, Social Mixing Patterns and Respiratory Symptoms in Seven Countries of the AfricanMeningitis Belt.www.plosone.org. July 2014 | Volume 9 | Issue7 Author Name: Claire F. Ferraro et al. 2014

Bacteriology Resources

Title Date Document Type Attachments
The Typhoid Fever Surveillance in Africa Program (TSAP): Clinical, Diagnostic, and Epidemiological Methodologies 2016-05-12 11:42 Publications, Bacteriology The Typhoid Fever Surveillance in Africa Program (TSAP).pdf
The Relationship Between Invasive Nontyphoidal Salmonella Disease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa 2016-05-12 11:41 Publications, Bacteriology The Relationship Between Invasive Nontyphoidal Clin Infect Dis.-2016-Park-S23-31(1).pdf
Bloodstream Infections and Frequency of Pretreatment Associated With Age and Hospitalization Status in Sub-Saharan Africa 2016-05-12 11:37 Publications, Bacteriology Bloodstream Infections and Frequency Clin Infect Dis.-2015-Nichols-S372-9.pdf
A Seroepidemiological Study of Serogroup A Meningococcal Infection in the African Meningitis Belt 2016-04-20 15:02 Publications, Bacteriology A Seroepidemiological Study of Serogroup A PLoS ONE Journal .pdf
Utilization of Healthcare in the Typhoid Fever Surveillance in Africa Program 2016-04-20 15:00 Publications, Bacteriology Utilization of Healthcare in the Typhoid Fever Surveillance Clin Infect Dis.-2016-Panzner-S56-68(1).pdf
Meningococcal carriage in the African meningitis belt 2015-09-15 12:36 Publications, Bacteriology Bacteriology 4.pdf
A pilot study on detection and genotyping of Human Papilloma virus isolated from clinically diagnosed Ethiopian women having cervical intraepithelial neoplasia 2015-09-15 12:33 Publications, Bacteriology Bacteriology 3.pdf
Chronic meningitis in immunocompromised adult Ethiopians visiting Tikur Anbessa Teaching Hospital and Ye’huleshet Clinic from 22003-2004 2015-09-15 12:26 Publications, Bacteriology Bacteriology 2.pdf
The Diversity of Meningococcal Carriage Acrossthe African Meningitis Belt and the Impact ofVaccination With a Group A MeningococcalConjugate Vaccine 2015-09-15 12:17 Publications, Bacteriology Bacteriology 1.pdf