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Malaria and Neglected Tropical Diseases

  Malaria and Neglected Tropical Diseases(MNTD)arch

About MNTD

The MNTD directorate is one of the directorates established by the Council of Minister’s Regulation No. 376/2016 with the objective of strengthening research, capacity building and networking in Malaria and Neglected Tropical diseases research. The focus of the directorate is to conduct quality basic biomedical, clinical and operational research for informed decision making and contribute to the global scientific knowledge.

MTND is a multidisciplinary group with staffs specialized in molecular mechanisms disease, tropical infectious diseases, Microbiology, Parasitology, Clinicians, public health specialists, Laboratory technologists, Health economist and GIS/Remote sensing specialist. We have strong team of laboratory researchers and Administration/Data science unit. As of January 2021, there are 6 PhD and 5 MSc students working with MNTD.

From 2006, MTND published over 77 articles in peer reviewed Journals. And over 25 MSc and PhD level thesis works were successfully defended.

MNTD is known for teamwork and resilience in continuing research and capacity building; Directorate members are working in the National Malaria Elimination Advisory committee, the National Leishmaniasis control program task force and National Onchocerciasis elimination Advisory committees. MNTD is active in giving fee professional services.

Research

Malaria Projects

  1. African centre for Plasmodium falciparum hrp2/3 deletion mapping (ACHIDES)
  2. Controlling emergent Anopheles stephensi in Ethiopia and Sudan (CEASE)
  3. Establishing An. arabiensis mosquitoes colony in Gonder (ColGo)
  4. Strengthen AHRI-Adama research- establish colony and evaluate egg desiccation resistance and oviposition traps for improved An. stephensi surveillance in Ethiopia to control the spread of an invasive malaria vector (Dessicate)
  5. Developing paediatric primaquine (DPP)
  6. Establishing the Ethiopian Malaria Genomic Epidemiology Network (EMAGEN)
  7. Assessing the contribution of seasonal migrant workers in selected districts of Northwest Amhara Region, Ethiopia to malaria transmission in midlands and highlands (HRP)
  8. Plasmodium falciparum infection dynamics and transmission to inform elimination (lNDlE)
  9. Modulation of transmission to mosquitoes during pregnancy (Preg)
  10. Evaluation of transmission of P. vivax from patients to mosquitoes before treatment and shortly after blood stage treatment (PvGam/AMMODO)
  11. Serological testing and treatment for P. vivax: from a cluster-randomised trial in Ethiopia and Madagascar to a mobile-technology supported intervention (PvSTATEM)
  12. Dynamics of transmission blocking immunity in P. vivax (PvTBI)
  13. Vector bionomics and mapping in the southern Ethiopia (SouthMap)
  14. Establishing Anopheles stephensi colony (Stephcolony)
  15. Initiate experimental studies on Anopheles stephensi biology and control (Stephbio)
  16. Ethiopia in-vivo efficacy study 2021: Therapeutic efficacy of AL or AP plus single dose PQ for the treatment of uncomplicated Plasmodium falciparum and CQ or AP plus 14 days PQ for uncomplicated Plasmodium vivax (TES2021)
  17. Evaluation of the effect of TMDA and RCD on malaria transmission and elimination in East Hararghe zone, Oromia, Ethiopia (tMDA)
  18. Epidemiology of malaria in selected urban and peri-urban centers of Ethiopia: Implication for prevention, control and elimination (UrbanMalaria)
  19. Collection of P. vivax biobank samples for serology test development (VISPA)

 Neglected Tropical Diseases (NTD) Projects

  1. African leishmaniasis: From clinical research to access (LeishAccess)
  2. A comparing 6 weeks of miltefosine with 6 weeks of systemic sodium stibogluconate in patients with complicated cutaneous leishmaniasis in Ethiopia) (MiSoLeish)
  3. Improving experiences and outcomes for individuals with severe stigmatizing skin diseases: Developing an integrated case finding and management intervention in Ghana and Ethiopia (SHARP)
  4. Safety of the Coadministration of Azithromycin, Albendazole, and Ivermectin Versus Standard Treatment Regimens during Mass Drug Administration (MDA) in Ethiopia (TripleCoAdmin)

Publications

2021

Bejano, S., G. Shumie, A. Kumar, E. Asemahagn, D. Damte, S. Woldie, A. Mulugeta, N. Manaye, A. Genetu, E. Gadisa and G. Mamo (2021). "Prevalence of asymptomatic visceral leishmaniasis in human and dog, Benishangul Gumuz regional state, Western Ethiopia." Parasit Vectors 14(1): 39.

Hailemeskel, E., S. K. Tebeje, S. Behaksra, G. Shumie, G. Shitaye, M. Keffale, W. Chali, A. Gashaw, T. Ashine, C. Drakeley, T. Bousema, E. Gadisa and F. G. Tadesse (2021). "The Epidemiology and Detectability of Asymptomatic Plasmodium Vivax and Plasmodium Falciparum Infections in Low, Moderate and High Transmission Settings in Ethiopia." Malar J 20, 59.

Molla, E., S.W. Behaksra, F. G. Tadesse, S. Dugassa, E. Gadisa and H. Mamo (2021). "Past eight-year malaria data in Gedeo zone, southern Ethiopia: trend, reporting-quality, spatiotemporal distribution, and association with socio-demographic and meteorological variables." BMC Infect Dis 21, 91.

Tadesse F. G., T. Ashine, H. Teka, E. Esayas, L. A. Messenger, W. Chali, L. Meerstein-Kessel, T. Walker, S. W. Behaksra, K. Lanke, R. Heutink, C. L. Jeffries, D. A. Mekonnen, E. Hailemeskel, S. K. Tebeje, T. Tafesse, A. Gashaw, T. Tsegaye, T. Emiru, K. Simon, E. A. Bogale, G. Yohannes, S. Kedir, G. Shumie, S. A. Sabir, P. Mumba, D. Dengela, J. H. Kolaczinski, A. Wilson, T. S. Churcher, S. Chibsa, M. Murphy, M. Balkew, S. Irish, C. Drakeley, E. Gadisa and T. Bousema (2021). "Anopheles stephensi mosquitoes as vectors of Plasmodium vivax and falciparum, Horn of Africa, 2019." Emerg Infect Dis. Vol. 27 No. 2. DOI: 10.3201/eid2702.200019

2020

Ayelign, B., M. Jemal, M. Negash, M. Genetu, T. Wondmagegn, A. J. Zeleke, L. Worku, A. G. Bayih, G. Shumie, S. W. Behaksra, T. Fenta, D. Damte, A. Yeshanew and E. Gadisa (2020). "Validation of in-house liquid direct agglutination test antigen: the potential diagnostic test in visceral Leishimaniasis endemic areas of Northwest Ethiopia." BMC Microbiol 20(1): 90.

Bisetegn, H., A. J. Zeleke, E. Gadisa, G. Shumie, D. Damte, T. Fenta, S. Behaksra and A. G. Bayih (2020). "Clinical, parasitological and molecular profiles of Cutaneous Leishmaniasis and its associated factors among clinically suspected patients attending Borumeda Hospital, North-East Ethiopia." PLoS Negl Trop Dis 14(8): e0008507.

Chali, W., T. Ashine, E. Hailemeskel, A. Gashaw, T. Tafesse, K. Lanke, E. Esayas, S. Kedir, G. Shumie, S. W. Behaksra, J. Bradley, D. Yewhalaw, H. Mamo, B. Petros, C. Drakeley, E. Gadisa, T. Bousema and F. G. Tadesse (2020). "Comparison of infectivity of Plasmodium vivax to wild-caught and laboratory-adapted (colonized) Anopheles arabiensis mosquitoes in Ethiopia." Parasit Vectors 13(1): 120.

Challi, S., H. Miecha, D. Damtie, G. Shumie, W. Chali, T. Hailu, T. T. Balcha, F. G. Tadesse and E. Gadisa (2020). "The Unmet Need: Low Performance of Laboratory Professionals in Malaria Microscopy, Oromia Regional State, Ethiopia." Am J Trop Med Hyg 102(1): 117-120.

Chanyalew, M., M. Abebe, B. Endale, S. Girma, G. Tasew, G. van Zandbergen, U. Ritter, E. Gadisa, A. Aseffa and T. Laskay (2020). "Enhanced production of pro-inflammatory cytokines and chemokines in Ethiopian cutaneous leishmaniasis upon exposure to Leishmania aethiopica." Cytokine: 155289.

de Jong, R. M., S. K. Tebeje, L. Meerstein-Kessel, F. G. Tadesse, M. M. Jore, W. Stone and T. Bousema (2020). "Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites." Immunol Rev 293(1): 190-215.

Eshetu, D., T. Shimelis, E. Nigussie, G. Shumie, W. Chali, B. Yeshitela, A. Assefa and E. Gadisa (2020). "Seropositivity to dengue and associated risk factors among non-malarias acute febrile patients in Arba Minch districts, southern Ethiopia." BMC Infect Dis 20(1): 639.

Ferede, G., M. Tiruneh, E. Abate, Y. Wondimeneh, E. Gadisa, R. Howe, A. Aseffa and B. Tessema (2020). "Evidence of chikungunya virus infection among febrile patients in northwest Ethiopia." Int J Infect Dis.

Nigussie, E., T. Shimelis, D. Eshetu, G. Shumie, W. Chali, A. Aseffa and E. Gadisa (2020). "Seropositivity of yellow fever virus among acute febrile patients attending selected health facilities in Borena district, Southern Ethiopia."  Ethiopian Medical Journal 58 (01)

Stresman, G., N. Sepulveda, K. Fornace, L. Grignard, J. Mwesigwa, J. Achan, J. Miller, D. J. Bridges, T. P. Eisele, J. Mosha, P. J. Lorenzo, M. L. Macalinao, F. E. Espino, F. Tadesse, J. C. Stevenson, A. M. Quispe, A. Siqueira, M. Lacerda, S. Yeung, S. Sovannaroth, E. Pothin, J. Gallay, K. E. Hamre, A. Young, J. F. Lemoine, M. A. Chang, K. Phommasone, M. Mayxay, J. Landier, D. M. Parker, L. Von Seidlein, F. Nosten, G. Delmas, A. Dondorp, E. Cameron, K. Battle, T. Bousema, P. Gething, U. D'Alessandro and C. Drakeley (2020). "Association between the proportion of Plasmodium falciparum and Plasmodium vivax infections detected by passive surveillance and the magnitude of the asymptomatic reservoir in the community: a pooled analysis of paired health facility and community data." Lancet Infect Dis 20(8): 953-963.

Tadesse, F. G., E. Gadisa, M. Balkew, P. Mumba, D. Yewhalaw, S. Chibsa and M. Haile (2020). "Synthesis of evidence on invasion and public health implication of an Asian mosquito vector (Anopheles stephensi) in Ethiopia." Special Bulletin - 22nd Annual Review Meeting of Health Sector Transformation Plan. Policy, Plan, Monitoring and Evaluation Directorate, Federal Ministry of Health of Ethiopia.

Tasew, G., E. Gadisa, A. Abera, M. Chanyalew, M. Abebe, R. Howe, U. Ritter, A. Aseffa and T. Laskay (2020). "Whole blood-based in vitro culture reveals diminished secretion of pro-inflammatory cytokines and chemokines in visceral leishmaniasis." Cytokine: 155246.

Tessema, S. K., M. Belachew, C. Koepfli, K. Lanke, T. Huwe, W. Chali, G. Shumie, E. F. Mekuria, C. Drakeley, E. Gadisa, B. Greenhouse, T. Bousema and F. G. Tadesse (2020). "Spatial and genetic clustering of Plasmodium falciparum and Plasmodium vivax infections in a low-transmission area of Ethiopia." Sci Rep 10(1): 19975.

Tuasha, N., D. Seifu, E. Gadisa, B. Petros and S. Oredsson (2020). "Solvent fractions of selected Ethiopian medicinal plants used in traditional breast cancer treatment inhibit cancer stem cells in a breast cancer cell line." BMC Complement Med Ther 20(1): 366.

2019

Aberra, L., A. Abera, T. Belay, A. Kebede, E. Gadisa and G. Tasew (2019). "Evaluation of microcapillary culture method for the isolation of Leishmania aethiopica parasites from patients with cutaneous lesions in Ethiopia." Diagn Progn Res 3: 4.

Gadisa, E. and K. Jote (2019). "Prevalence and factors associated with intestinal parasitic infection among under-five children in and around Haro Dumal Town, Bale Zone, Ethiopia." BMC Pediatr 19(1): 385.

Gadisa, E., G. Weldearegay, K. Desta, G. Tsegaye, S. Hailu, K. Jote and A. Takele (2019). "Combined antibacterial effect of essential oils from three most commonly used Ethiopian traditional medicinal plants on multidrug resistant bacteria." BMC Complement Altern Med 19(1): 24.

Hailemeskel, E., T. Menberu, G. Shumie, S. Behaksra, W. Chali, M. Keffale, M. Belachew, G. Shitaye, H. Mohammed, D. Abebe, T. Ashine, C. Drakeley, H. Mamo, B. Petros, T. Bousema, F. G. Tadesse and E. Gadisa (2019). "Prevalence of Plasmodium falciparum Pfcrt and Pfmdr1 alleles in settings with different levels of Plasmodium vivax co-endemicity in Ethiopia." Int J Parasitol Drugs Drug Resist 11: 8-12.

Kebede, A. M., F. G. Tadesse, A. D. Feleke, L. Golassa and E. Gadisa (2019). "Effect of low complexity regions within the PvMSP3alpha block II on the tertiary structure of the protein and implications to immune escape mechanisms." BMC Struct Biol 19(1): 6.

Keffale, M., G. Shumie, S. W. Behaksra, W. Chali, L. Hoogen, E. Hailemeskel, D. Mekonnen, M. Chanyalew, D. Damte, T. Fanta, T. Ashine, S. Chali, K. K. A. Tetteh, D. D. Birhanu, T. T. Balcha, A. Aseffa, C. Drakeley, T. S. Tessema, H. Adamu, T. Bousema, E. Gadisa and F. G. Tadesse (2019). "Serological evidence for a decline in malaria transmission following major scale-up of control efforts in a setting selected for Plasmodium vivax and Plasmodium falciparum malaria elimination in Babile district, Oromia, Ethiopia." Trans R Soc Trop Med Hyg 113(6): 305-311.

Slater, H. C., A. Ross, I. Felger, N. E. Hofmann, L. Robinson, J. Cook, B. P. Goncalves, A. Bjorkman, A. L. Ouedraogo, U. Morris, M. Msellem, C. Koepfli, I. Mueller, F. Tadesse, E. Gadisa, S. Das, G. Domingo, M. Kapulu, J. Midega, S. Owusu-Agyei, C. Nabet, R. Piarroux, O. Doumbo, S. N. Doumbo, K. Koram, N. Lucchi, V. Udhayakumar, J. Mosha, A. Tiono, D. Chandramohan, R. Gosling, F. Mwingira, R. Sauerwein, R. Paul, E. M. Riley, N. J. White, F. Nosten, M. Imwong, T. Bousema, C. Drakeley and L. C. Okell (2019). "Author Correction: The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density." Nat Commun 10(1): 2644.

Slater, H. C., A. Ross, I. Felger, N. E. Hofmann, L. Robinson, J. Cook, B. P. Goncalves, A. Bjorkman, A. L. Ouedraogo, U. Morris, M. Msellem, C. Koepfli, I. Mueller, F. Tadesse, E. Gadisa, S. Das, G. Domingo, M. Kapulu, J. Midega, S. Owusu-Agyei, C. Nabet, R. Piarroux, O. Doumbo, S. N. Doumbo, K. Koram, N. Lucchi, V. Udhayakumar, J. Mosha, A. Tiono, D. Chandramohan, R. Gosling, F. Mwingira, R. Sauerwein, R. Paul, E. M. Riley, N. J. White, F. Nosten, M. Imwong, T. Bousema, C. Drakeley and L. C. Okell (2019). "The temporal dynamics and infectiousness of subpatent Plasmodium falciparum infections in relation to parasite density." Nat Commun 10(1): 1433.

Tadesse, F. G., L. Meerstein-Kessel, B. P. Goncalves, C. Drakeley, L. Ranford-Cartwright and T. Bousema (2019). "Gametocyte Sex Ratio: The Key to Understanding Plasmodium falciparum Transmission?" Trends Parasitol 35(3): 226-238.

Tadesse, F. (2019). Behind the paper: Heavy coolboxes, burning cars and invading cockroaches. Nature Microbiology blog. March 2019; https://go.nature.com/2HOxb7W.

Tuasha, N., D. Seifu, E. Gadisa, B. Petros and S. Oredsson (2019). "Cytotoxicity of selected Ethiopian medicinal plants used in traditional breast cancer treatment against breast-derived cell lines. " Journal of Medicinal Plants Research, 13(9), 188-198.

2018

Ferede, G., M. Tiruneh, E. Abate, Y. Wondimeneh, D. Damtie, E. Gadisa, R. Howe, A. Aseffa and B. Tessema (2018). "A serologic study of dengue in northwest Ethiopia: Suggesting preventive and control measures." PLoS Negl Trop Dis 12(5): e0006430.

Ferede, G., M. Tiruneh, E. Abate, Y. Wondimeneh, E. Gadisa, R. Howe, A. Aseffa and B. Tessema (2018). "A study of clinical, hematological, and biochemical profiles of patients with dengue viral infections in Northwest Ethiopia: implications for patient management." BMC Infect Dis 18(1): 616.

Olliaro, P., M. Grogl, M. Boni, E. M. Carvalho, H. Chebli, M. Cisse, E. Diro, G. Fernandes Cota, A. C. Erber, E. Gadisa, F. Handjani, A. Khamesipour, A. Llanos-Cuentas, L. Lopez Carvajal, L. Grout, B. E. Lmimouni, M. Mokni, M. S. Nahzat, A. Ben Salah, Y. Ozbel, J. M. Pascale, N. Rizzo Molina, J. Rode, G. Romero, J. A. Ruiz-Postigo, N. Gore Saravia, J. Soto, S. Uzun, V. Mashayekhi, I. D. Velez, F. Vogt, O. Zerpa and B. Arana (2018). "Harmonized clinical trial methodologies for localized cutaneous leishmaniasis and potential for extensive network with capacities for clinical evaluation." PLoS Negl Trop Dis 12(1): e0006141.

Shitaye, G., E. Gadisa, L. Grignard, G. Shumie, W. Chali, T. Menberu, M. Belachew, G. Tegegn, S. Challi, J. Curry, L. Mahey, T. Hailu, H. Mamo, M. Menon, T. Balcha, A. Aseffa, C. Drakeley, T. Bousema and F. G. Tadesse (2018). "Low and heterogeneous prevalence of glucose-6-phosphate dehydrogenase deficiency in different settings in Ethiopia using phenotyping and genotyping approaches." Malar J 17(1): 281.

Tadesse, F. G., H. C. Slater, W. Chali, K. Teelen, K. Lanke, M. Belachew, T. Menberu, G. Shumie, G. Shitaye, L. C. Okell, W. Graumans, G. J. van Gemert, S. Kedir, A. Tesfaye, F. Belachew, W. Abebe, H. Mamo, R. Sauerwein, T. Balcha, A. Aseffa, D. Yewhalaw, E. Gadisa, C. Drakeley and T. Bousema (2018). "The Relative Contribution of Symptomatic and Asymptomatic Plasmodium vivax and Plasmodium falciparum Infections to the Infectious Reservoir in a Low-Endemic Setting in Ethiopia." Clin Infect Dis 66(12): 1883-1891.

Taylor, W. R., H. K. Naw, K. Maitland, T. N. Williams, M. Kapulu, U. D'Alessandro, J. A. Berkley, P. Bejon, J. Okebe, J. Achan, A. N. Amambua, M. Affara, D. Nwakanma, J. P. van Geertruyden, M. Mavoko, P. Lutumba, J. Matangila, P. Brasseur, P. Piola, R. Randremanana, E. Lasry, C. Fanello, M. Onyamboko, B. Schramm, Z. Yah, J. Jones, R. M. Fairhurst, M. Diakite, G. Malenga, M. Molyneux, C. Rwagacondo, C. Obonyo, E. Gadisa, A. Aseffa, M. Loolpapit, M. C. Henry, G. Dorsey, C. John, S. B. Sirima, K. I. Barnes, P. Kremsner, N. P. Day, N. J. White and M. Mukaka (2018). "Single low-dose primaquine for blocking transmission of Plasmodium falciparum malaria - a proposed model-derived age-based regimen for sub-Saharan Africa." BMC Med 16(1): 11.

2017

Gadisa, E., G. Tasew, A. Abera, W. Gelaye, M. Chanyalew, M. Abebe, T. Laskay and A. Aseffa (2017). "Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis." Cytokine 91: 6-9.

Graumans, W., F. G. Tadesse, C. Andolina, G. J. van Gemert, K. Teelen, K. Lanke, E. Gadisa, D. Yewhalaw, M. van de Vegte-Bolmer, R. Siebelink-Stoter, I. Reuling, R. Sauerwein and T. Bousema (2017). "Semi-high-throughput detection of Plasmodium falciparum and Plasmodium vivax oocysts in mosquitoes using bead-beating followed by circumsporozoite ELISA and quantitative PCR." Malar J 16(1): 356.

Tadesse, F. G., K. Lanke, I. Nebie, J. A. Schildkraut, B. P. Goncalves, A. B. Tiono, R. Sauerwein, C. Drakeley, T. Bousema and S. R. Rijpma (2017). "Molecular Markers for Sensitive Detection of Plasmodium falciparum Asexual Stage Parasites and their Application in a Malaria Clinical Trial." Am J Trop Med Hyg 97(1): 188-198.

Tadesse, F. G., L. van den Hoogen, K. Lanke, J. Schildkraut, K. Tetteh, A. Aseffa, H. Mamo, R. Sauerwein, I. Felger, C. Drakeley, E. Gadissa and T. Bousema (2017). "The shape of the iceberg: quantification of submicroscopic Plasmodium falciparum and Plasmodium vivax parasitaemia and gametocytaemia in five low endemic settings in Ethiopia." Malar J 16(1): 99.

2016

Abera, A., G. Tasew, A. Degu, M. Almneh, A. Mulugeta, A. Aseffa and E. Gadisa (2016). "Visceral Leishmaniasis from an Area Previously Not Known to Be Endemic; Dangur, Benshangul-Gumuz, Regional State, Northwest Ethiopia: A Case Report." Ethiop Med J 54(1): 33-36.

Abera, A., G. Tasew, T. Tsegaw, A. Kejella, A. Mulugeta, D. Worku, A. Aseffa and E. Gadisa (2016). "Visceral Leishmaniasis in Benishangul-Gumuz Regional State, Western Ethiopia: Reemerging or Emerging?" Am J Trop Med Hyg 95(1): 104-108.

Chang, H. H., E. Meibalan, J. Zelin, R. Daniels, A. C. Eziefula, E. C. Meyer, F. Tadesse, L. Grignard, R. C. Joice, C. Drakeley, D. F. Wirth, S. K. Volkman, C. Buckee, T. Bousema and M. Marti (2016). "Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda." Sci Rep 6: 26330.

Gadisa, E., E. Salamanca, A. Aseffa, J. C. Ticona, E. Udaeta, N. Flores, R. Chuqui and A. Giménez (2016). "Susceptibility studies on Leishmania aethiopica strains against total alkaloids from Galipea longiflora (Evanta)." Rev.Cs.Farm. y Bioq, vol.4, n.2

Tasew, G., E. Gadisa, A. Abera, A. Zewude, M. Chanyalew, A. Aseffa, M. Abebe, U. Ritter, G. van Zandbergen, T. Laskay and K. Tafess (2016). "In vitro permissiveness of bovine neutrophils and monocyte derived macrophages to Leishmania donovani of Ethiopian isolate." Parasit Vectors 9: 218.

van Griensven, J., E. Gadisa, A. Aseffa, A. Hailu, A. M. Beshah and E. Diro (2016). "Treatment of Cutaneous Leishmaniasis Caused by Leishmania aethiopica: A Systematic Review." PLoS Negl Trop Dis 10(3): e0004495.

2015

Berg, S., E. Schelling, E. Hailu, R. Firdessa, B. Gumi, G. Erenso, E. Gadisa, A. Mengistu, M. Habtamu, J. Hussein, T. Kiros, S. Bekele, W. Mekonnen, Y. Derese, J. Zinsstag, G. Ameni, S. Gagneux, B. D. Robertson, R. Tschopp, G. Hewinson, L. Yamuah, S. V. Gordon and A. Aseffa (2015). "Investigation of the high rates of extrapulmonary tuberculosis in Ethiopia reveals no single driving factor and minimal evidence for zoonotic transmission of Mycobacterium bovis infection." BMC Infect Dis 15: 112.

Bsrat, A., N. Berhe, M. Balkew, M. Yohannes, T. Teklu, E. Gadisa, G. Medhin and A. Abera (2015). "Epidemiological study of cutaneous leishmaniasis in Saesie Tsaeda-emba district, eastern Tigray, northern Ethiopia." Parasit Vectors 8: 149.

Gadisa, E., T. Tsegaw, A. Abera, D. E. Elnaiem, M. den Boer, A. Aseffa and A. Jorge (2015). "Eco-epidemiology of visceral leishmaniasis in Ethiopia." Parasit Vectors 8: 381.

Getachew, S., K. Thriemer, S. Auburn, A. Abera, E. Gadisa, A. Aseffa, R. N. Price and B. Petros (2015). "Chloroquine efficacy for Plasmodium vivax malaria treatment in southern Ethiopia." Malar J 14: 525.

Herrador, Z., J. Perez-Formigo, L. Sordo, E. Gadisa, J. Moreno, A. Benito, A. Aseffa and E. Custodio (2015). "Low Dietary Diversity and Intake of Animal Source Foods among School Aged Children in Libo Kemkem and Fogera Districts, Ethiopia." PLoS One 10(7): e0133435.

Maru, M., S. H. Mariam, T. Airgecho, E. Gadissa and A. Aseffa (2015). "Prevalence of Tuberculosis, Drug Susceptibility Testing, and Genotyping of Mycobacterial Isolates from Pulmonary Tuberculosis Patients in Dessie, Ethiopia." Tuberculosis Research and Treatment, vol. 2015, Article ID 215015

Solomon, N., K. V. Suryabhagavan and E. Gadisa (2015). "Visceral Leishmaniasis (Kala-Azar) Risk Mapping using Geo-Spatial Tools: A Case Study in Kafta Humera District, North Western Ethiopia." International Journal of Geoinformatics 11 (1)

Tadesse, F. G., N. Mensali, L. E. Fallang, E. Walseng, W. Yang, J. Olweus and S. Walchli (2015). "Unpredicted phenotypes of two mutants of the TcR DMF5." J Immunol Methods 425: 37-44.

Tadesse, F. G., H. Pett, A. Baidjoe, K. Lanke, L. Grignard, C. Sutherland, T. Hall, C. Drakeley, T. Bousema and H. Mamo (2015). "Submicroscopic carriage of Plasmodium falciparum and Plasmodium vivax in a low endemic area in Ethiopia where no parasitaemia was detected by microscopy or rapid diagnostic test." Malar J 14: 303.

2014

Aseffa, A., A. Mihret, A. Habte, E. Gadisa and D. Beyene (2014). "Seizing the opportunity for better organization of health research." Ethiop Med J Suppl 1: 2 p preceding 1.

Bekele, S., Y. Bekele, F. Mulatu, T. Lemma, H. Tilahun, E. Gadisa, S. Negussie, L. Yamuah, L. Wassie, M. Abebe, M. Hiletework, M. Hunegnaw, R. Leekassa and E. Bizuneh (2014). "Recent trends of cutaneous leishmaniasis in Alert Hospital, Addis Ababa." Ethiop Med J Suppl 1: 37-41.

Bezabih, M., A. Abdissa, E. Gadisa and A. Aseffa (2014). "Patterns of enlarged cervical lymph nodes among HIV positive and negative patients in southwestern Ethiopia: a cytopathlogic analysis." Ethiop Med J 52(1): 19-25.

Herrador, Z., L. Sordo, E. Gadisa, A. Buno, R. Gomez-Rioja, J. M. Iturzaeta, L. F. de Armas, A. Benito, A. Aseffa, J. Moreno, C. Canavate and E. Custodio (2014). "Micronutrient deficiencies and related factors in school-aged children in Ethiopia: a cross-sectional study in Libo Kemkem and Fogera districts, Amhara Regional State." PLoS One 9(12): e112858.

Herrador, Z., L. Sordo, E. Gadisa, J. Moreno, J. Nieto, A. Benito, A. Aseffa, C. Canavate and E. Custodio (2014). "Cross-sectional study of malnutrition and associated factors among school aged children in rural and urban settings of Fogera and Libo Kemkem districts, Ethiopia." PLoS One 9(9): e105880.

Lopez-Perea, N., L. Sordo, E. Gadisa, I. Cruz, T. Hailu, J. Moreno, A. Aseffa, C. Canavate and E. Custodio (2014). "Knowledge, attitudes and practices related to visceral leishmaniasis in rural communities of Amhara State: a longitudinal study in northwest Ethiopia." PLoS Negl Trop Dis 8(4): e2799.

Seid, A., E. Gadisa, T. Tsegaw, A. Abera, A. Teshome, A. Mulugeta, M. Herrero, D. Argaw, A. Jorge, A. Kebede and A. Aseffa (2014). "Risk map for cutaneous leishmaniasis in Ethiopia based on environmental factors as revealed by geographical information systems and statistics." Geospat Health 8(2): 377-387.

2013

Firdessa, R., S. Berg, E. Hailu, E. Schelling, B. Gumi, G. Erenso, E. Gadisa, T. Kiros, M. Habtamu, J. Hussein, J. Zinsstag, B. D. Robertson, G. Ameni, A. J. Lohan, B. Loftus, I. Comas, S. Gagneux, R. Tschopp, L. Yamuah, G. Hewinson, S. V. Gordon, D. B. Young and A. Aseffa (2013). "Mycobacterial lineages causing pulmonary and extrapulmonary tuberculosis, Ethiopia." Emerg Infect Dis 19(3): 460-463.

Tsegaw, T., E. Gadisa, A. Seid, A. Abera, A. Teshome, A. Mulugeta, M. Herrero, D. Argaw, A. Jorge and A. Aseffa (2013). "Identification of environmental parameters and risk mapping of visceral leishmaniasis in Ethiopia by using geographical information systems and a statistical approach." Geospat Health 7(2): 299-308.

2012

Custodio, E., E. Gadisa, L. Sordo, I. Cruz, J. Moreno, J. Nieto, C. Chicharro, A. Aseffa, Z. Abraham, T. Hailu and C. Canavate (2012). "Factors associated with Leishmania asymptomatic infection: results from a cross-sectional survey in highland northern Ethiopia." PLoS Negl Trop Dis 6(9): e1813.

Gadisa, E., E. Custodio, C. Canavate, L. Sordo, Z. Abebe, J. Nieto, C. Chicharro, A. Aseffa, L. Yamuah, H. Engers, J. Moreno and I. Cruz (2012). "Usefulness of the rK39-immunochromatographic test, direct agglutination test, and leishmanin skin test for detecting asymptomatic Leishmania infection in children in a new visceral leishmaniasis focus in Amhara State, Ethiopia." Am J Trop Med Hyg 86(5): 792-798.

Negera, E., E. Gadisa, J. Hussein, H. Engers, T. Kuru, L. Gedamu and A. Aseffa (2012). "Treatment response of cutaneous leishmaniasis due to Leishmania aethiopica to cryotherapy and generic sodium stibogluconate from patients in Silti, Ethiopia." Trans R Soc Trop Med Hyg 106(8): 496-503.

Sordo, L., E. Gadisa, E. Custodio, I. Cruz, F. Simon, Z. Abraham, J. Moreno, A. Aseffa, H. Tsegaye, J. Nieto, C. Chicharro and C. Canavate (2012). "Low prevalence of Leishmania infection in post-epidemic areas of Libo Kemkem, Ethiopia." Am J Trop Med Hyg 86(6): 955-958.

2011

Kuru, T., N. Janusz, E. Gadisa, L. Gedamu and A. Aseffa (2011). "Leishmania aethiopica: development of specific and sensitive PCR diagnostic test." Exp Parasitol 128(4): 391-395.

2010

Gadisa, E., T. Kuru, A. Genet, H. Engers, A. Aseffa and L. Gedamu (2010). "Leishmania donovani complex (Kinetoplastida, Trypanosomatidae): comparison of deoxyribonucleic acid based techniques for typing of isolates from Ethiopia." Exp Parasitol 126(2): 203-208.

Tschopp, R., A. Aseffa, E. Schelling, S. Berg, E. Hailu, E. Gadisa, M. Habtamu, K. Argaw and J. Zinsstag (2010). "Bovine tuberculosis at the wildlife-livestock-human interface in Hamer Woreda, South Omo, Southern Ethiopia." PLoS One 5(8): e12205.

Tschopp, R., S. Berg, K. Argaw, E. Gadisa, M. Habtamu, E. Schelling, D. Young, A. Aseffa and J. Zinsstag (2010). "Bovine tuberculosis in Ethiopian wildlife." J Wildl Dis 46(3): 753-762.

2009

Berg, S., R. Firdessa, M. Habtamu, E. Gadisa, A. Mengistu, L. Yamuah, G. Ameni, M. Vordermeier, B. D. Robertson, N. H. Smith, H. Engers, D. Young, R. G. Hewinson, A. Aseffa and S. V. Gordon (2009). "The burden of mycobacterial disease in ethiopian cattle: implications for public health." PLoS One 4(4): e5068.

Lemma, W., G. Erenso, E. Gadisa, M. Balkew, T. Gebre-Michael and A. Hailu (2009). "A zoonotic focus of cutaneous leishmaniasis in Addis Ababa, Ethiopia." Parasit Vectors 2(1): 60.

Tasew, G., A. Kebede, D. Wolday, E. Gadisa, S. Britton, L. Eidsmo and H. Akuffo (2009). "Low-cost liquid medium for in vitro cultivation of Leishmania parasites in low-income countries." Glob Health Action 2.

2008

Negera, E., E. Gadisa, L. Yamuah, H. Engers, J. Hussein, T. Kuru, A. Hailu, L. Gedamu and A. Aseffa (2008). "Outbreak of cutaneous leishmaniasis in Silti woreda, Ethiopia: risk factor assessment and causative agent identification." Trans R Soc Trop Med Hyg 102(9): 883-890.

2007

Gadisa, E., A. Genetu, T. Kuru, D. Jirata, K. Dagne, A. Aseffa and L. Gedamu (2007). "Leishmania (Kinetoplastida): species typing with isoenzyme and PCR-RFLP from cutaneous leishmaniasis patients in Ethiopia." Exp Parasitol 115(4): 339-343.

2006

Genetu, A., E. Gadisa, A. Aseffa, S. Barr, M. Lakew, D. Jirata, T. Kuru, D. Kidane, M. Hunegnaw and L. Gedamu (2006). "Leishmania aethiopica: strain identification and characterization of superoxide dismutase-B genes." Exp Parasitol 113(4): 221-226.

Researchers at MNTD 

No.

  Name

Position

1

 Dr. Sagni Chali

Director

2

 Dr. Endalamaw Gadisa

Senior Scientist

3

 Dr. Fitsum Girma

Lead Scientist

4

 Tesfaye Tsega

Project Manager

5

 Aklilu Adane

Project Manager

6

 Fikregabrail Aberra

Associate Researcher

7

 Dr. Yohannes H/Michael

Post-Doctoral Researcher

8

 Dr. Yhenew Asmamaw

Post-Doctoral Researcher

9

 Dr. Migbaru Kefale

Researcher

10

 Demekech Damte

Researcher

11

 Endashaw Esayas

Associate Researcher

12

 Eshetu Molla Belete

Associate Researcher

13

 Girma Shumie

Associate Researcher

14

 Temesgen Ashine

Associate Researcher

15

 Temesgen Tafese

Associate Researcher

16

 Sinknesh Wolde

Associate Researcher

17

 Wakweya Chali

Associate Researcher

18

 Abena Kochora

Assistant Researcher

19

 Daniel Mussa

Assistant Researcher

20

 Debisa Eshetu

Assistant Researcher

21

 Derese Bekele

Assistant Researcher

22

 Haile Abera

Assistant Researcher

23

 Kidist W/Kidan

Assistant Researcher

24

 Jimma Dinsa

Assistant Researcher

25

 Legesse Alamire

Assistant Researcher

26

 Mikiyas Gebremichael

Assistant Researcher

27

 Mosisa Bekele

Assistant Researcher

28

 Muluken Assefa

Assistant Researcher

29

 Nebiyu Sherefa

Assistant Researcher

30

 Nigatu Negash

Assistant Researcher

31

 Tadele Emiru

Assistant Researcher

32

 Tizita Tsegaye

Assistant Researcher

33

 Yematawork Kebede

Assistant Researcher

34

 Abrham Gashaw

Junior Researcher

35

 Addisu Gizat

Junior Researcher

36

 Amanuel Shimelash

Junior Researcher

37

 Anteneh Eyesus

Junior Researcher

38

 Desalegn Nibret

Junior Researcher

39

 Elias Bekele

Junior Researcher

40

 Eyob Befekadu

Junior Researcher

41

 Fikadesilassie Mozart

Junior Researcher

42

 Gutema Jebessa

Junior Researcher

43

 Kassahun Abi

Junior Researcher

44

 Kebede Getachew

Junior Researcher

45

 Lina Alemayehu

Junior Researcher

46

 Matiwos Kidane

Junior Researcher

47

 Melaku Petros

Junior Researcher

48

 Melat Abdo

Junior Researcher

49

 Mengist Engidaw

Junior Researcher

50

 Meskele Dechasa

Junior Researcher

51

 Mulugeta Demssie

Junior Researcher

52

 Natnael Lemessa

Junior Researcher

53

 Sinshaw Legese

Junior Researcher

54

 Teklu Cherkose

Junior Researcher

55

 Tigist Atele

Junior Researcher

56

 Zemed Biyazn

Junior Researcher

57

 Zewedu Solomon

Junior Researcher

58

 Eyerusalem Tesfaye

Project Coordinator

59

 Getinet Habtamu

Project Coordinator

60

 Addisu Assefa

Project Coordinator

61

 Amanuel Albene

Laboratory Coordinator

62

 Betelhem Yitbarek

Project Accountant

63

 Tirhas Endale

Malaria Microscopist

64

 Medina Hassen

Quality Assurance

65

 Hunyalew Adane

Junior Administration Officer

 

Post Graduate Students

      PhD students

No.
    Name
  AHRI Advisor(s)
1
Abebaw Yeshambel
Endalamaw Gadisa (PhD) and Fitsum Girma (PhD)
2
Alemayehu Letebo
Fitsum Girma (PhD)
3
Ayalew Jejaw
Fitsum Girma (PhD)
4
Daniel Abebe
Endalamaw Gadisa (PhD) and Fitsum Girma (PhD)
5
Elifaged H/meskel
Endalamaw Gadisa (PhD) and Fitsum Girma (PhD)
6
Eshetu Molla
Endalamaw Gadisa (PhD) and Fitsum Girma (PhD)
7
Feleke Tilahun
Endalamaw Gadisa (PhD)
8
Girma Shumye
Endalamaw Gadisa (PhD)
9
Hiwot Teka
Endalamaw Gadisa (PhD) and Fitsum Girma (PhD)
10
Migbaru Keffale
Fitsum Girma (PhD)
11
Misrak Abraham
Endalamaw Gadisa (PhD), Fitsum Girma (PhD) and Yehenew Asmamaw (PhD)
12
Sinknesh Wolde
Endalamaw Gadisa (PhD) and Fitsum Girma (PhD)
13
Surafel Kefyalew
Endalamaw Gadisa (PhD) and Fitsum Girma (PhD)
14
Takele Gezahegni
Endalamaw Gadisa (PhD)
15
Temesgen Ashine
Endalamaw Gadisa (PhD) and Yehenew Asmamaw (PhD)
16
Wakweya Chali
Fitsum Girma (PhD)

       M.Sc. students

No.
     Name
AHRI Advisor(s)
1
Abel Belyu
Fitsum Girma (PhD) and Migbaru Keffale
2
Alayu Bogale
Fitsum Girma (PhD) and Migbaru Keffale
3
Masame Tadesse
Endalamaw Gadisa (PhD) and Teklu Cherkosie
4
Melat Abdo
Endalamaw Gadisa (PhD) and Fistum Girma (PhD)
5
Tadesse Misganaw
Fitsum Girma (PhD) and Migbaru Keffale
6
Tajudin Abdurahman
Fitsum Girma (PhD) and Migbaru Keffale
7
Wagari Tafesse
Endalamaw Gadisa (PhD) and Teklu Cherkosie
8
Yasin Nasir
Fitsum Girma (PhD) and Migbaru Keffale
9
Zufan Yiheyis
Fitsum Girma (PhD) and Migbaru Keffale
 

Contact

Dr. Sagni Chali
Director, Malaria and NTD Directorate (MNTD)
Email: sagni.chali@ahri.gov.et
Tel: +25191138014